Genomics and pathogenesis of the avian coronavirus infectious bronchitis virus

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dc.contributor.authorQuinteros, JA
dc.contributor.authorNoormohammadi, AH
dc.contributor.authorLee, SW
dc.contributor.authorBrowning, GF
dc.contributor.authorDiaz-Méndez, A
dc.date.accessioned2022-11-07T12:14:53Z
dc.date.available2022-11-07T12:14:53Z
dc.date.issued2022-08-17
dc.description.abstractInfectious bronchitis virus (IBV) is a member of the family Coronaviridae, together with viruses such as SARS-CoV, MERS-CoV and SARS-CoV-2 (the causative agent of the COVID-19 global pandemic). In this family of viruses, interspecies transmission has been reported, so understanding their pathobiology could lead to a better understanding of the emergence of new serotypes. IBV possesses a single-stranded, non-segmented RNA genome about 27.6 kb in length that encodes several non-structural and structural proteins. Most functions of these proteins have been confirmed in IBV, but some other proposed functions have been based on research conducted on other members of the family Coronaviridae. IBV has variable tissue tropism depending on the strain, and can affect the respiratory, reproductive, or urinary tracts; however, IBV can also replicate in other organs. Additionally, the pathogenicity of IBV is also variable, with some strains causing only mild clinical signs, while infection with others results in high mortality rates in chickens. This paper extensively and comprehensibly reviews general aspects of coronaviruses and, more specifically, IBV, with emphasis on protein functions and pathogenesis. The pathogenicity of the Australian strains of IBV is also reviewed, describing the variability between the different groups of strains, from the classical to the novel and recombinant strains. Reverse genetic systems, cloning and cell culture growth techniques applicable to IBV are also reviewed.es_ES
dc.identifier.issn1751-0813
dc.identifier.other10.1111/avj.13197
dc.identifier.urihttps://hdl.handle.net/20.500.12536/1852
dc.language.isoenes_ES
dc.sourceAustralian Veterinary Journales_ES
dc.subjectAvian coronaviruses_ES
dc.subjectCloninges_ES
dc.subjectGeneticses_ES
dc.subjectIBVes_ES
dc.subjectInfectious bronchitises_ES
dc.subjectPathogenesises_ES
dc.subjectProtein functionses_ES
dc.titleGenomics and pathogenesis of the avian coronavirus infectious bronchitis viruses_ES
dc.typeArtículo de revistaes_ES
uvm.carreraMedicina Veterinariaes_ES
uvm.escuelaEscuela de Ciencias Agrícolas y Veterinariases_ES
uvm.indexWoSes_ES
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