Quercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Rats

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dc.contributor.authorCastillo, Rodrigo L.
dc.contributor.authorHerrera, Emilio A.
dc.contributor.authorGonzalez-Candia, Alejandro
dc.contributor.authorReyes-Farias, Marjorie
dc.contributor.authorde la Jara, Nicole
dc.contributor.authorPeña, Juan Pedro
dc.contributor.authorCarrasco-Pozo, Catalina
dc.date.accessioned2019-07-15T07:45:48Z
dc.date.available2019-07-15T07:45:48Z
dc.date.issued2018
dc.description.abstractAlterations in cardiac energy metabolism play a key role in the pathogenesis of diabetic cardiomyopathy. Hypercholesterolemia associated with bioenergetic impairment and oxidative stress has not been well characterized in the cardiac function under glycemic control deficiency conditions. This work aimed to determine the cardioprotective effects of quercetin (QUE) against the damage induced by a high-cholesterol (HC) diet in hyperglycemic rats, addressing intracellular antioxidant mechanisms and bioenergetics. Quercetin reduced HC-induced alterations in the lipid profile and glycemia in rats. In addition, QUE attenuated cardiac diastolic dysfunction (increased E:A ratio), prevented cardiac cholesterol accumulation, and reduced the increase in HC-induced myocyte density. Moreover, QUE reduced HC-induced oxidative stress by preventing the decrease in GSH/GSSG ratio, Nrf2 nuclear translocation, HO-1 expression, and antioxidant enzymatic activity. Quercetin also counteracted HCinduced bioenergetic impairment, preventing a reduction in ATP levels and alterations in PGC-1α, UCP2, and PPARγ expression. In conclusion, the mechanisms that support the cardioprotective effect of QUE in rats with HC might be mediated by the upregulation of antioxidant mechanisms and improved bioenergetics on the heart. Targeting bioenergetics with QUE can be used as a pharmacological approach to modulate structural and functional changes of the heart under hypercholesterolemic and hyperglycemic conditions.es_ES
dc.identifier.issn1942-0900
dc.identifier.other10.1155/2018/7239123
dc.identifier.urihttps://hdl.handle.net/20.500.12536/95
dc.language.isoenes_ES
dc.sourceOxidative Medicine and Cellular Longevity (HINDAWI)es_ES
dc.titleQuercetin Prevents Diastolic Dysfunction Induced by a High-Cholesterol Diet: Role of Oxidative Stress and Bioenergetics in Hyperglycemic Ratses_ES
dc.typeArtículo de revistaes_ES
uvm.carreraMedicina veterinariaes_ES
uvm.escuelaEscuela de Ciencias Veterinariases_ES
uvm.indexScopuses_ES
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