The Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Model

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dc.contributor.authorBuendía, Débora
dc.contributor.authorGuncay, Tatiana
dc.contributor.authorOyanedel, Macarena
dc.contributor.authorLemus, Makarena
dc.contributor.authorWeinstein, Alejandro
dc.contributor.authorArdiles, Álvaro O.
dc.contributor.authorMarcos, José
dc.contributor.authorFernandes, Adriana
dc.contributor.authorZângaro, Renato
dc.contributor.authorMuñoz, Pablo
dc.date.accessioned2022-09-30T19:26:10Z
dc.date.available2022-09-30T19:26:10Z
dc.date.issued2022-09-21
dc.description.abstractAlzheimer’s disease (AD) is the main cause of dementia worldwide. Emerging noninvasive treatments such as photobiomodulation target the mitochondria to minimize brain damage, improving cognitive functions. In this work, an experimental design was carried out to evaluate the effect of transcranial light therapy (TLTC) on synaptic plasticity (SP) and cognitive functions in an AD animal model. Twenty-three mice were separated into two general groups: an APP/PS1 (ALZ) transgenic group and a wild-type (WT) group. Each group was randomly subdivided into two subgroups: mice with and without TLTC, depending on whether they would undergo treatment with TLTC. Cognitive function, measured through an object recognition task, showed non-significant improvement after TLTC. SP, on the other hand, was evaluated using four electrophysiological parameters from the Schaffer-CA1 collateral hippocampal synapses: excitatory field potentials (fEPSP), paired pulse facilitation (PPF), long-term depression (LTD), and long-term potentiation (LTP). An improvement was observed in subjects treated with TLTC, showing higher levels of LTP than those transgenic mice that were not exposed to the treatment. Therefore, the results obtained in this work showed that TLTC could be an efficient non-invasive treatment for AD-associated SP deficits.es_ES
dc.identifier.issn2076-3425
dc.identifier.other10.3390/brainsci12101272
dc.identifier.urihttps://hdl.handle.net/20.500.12536/1803
dc.language.isoeses_ES
dc.sourceBrain Scienceses_ES
dc.subjectAlzheimer’s diseasees_ES
dc.subjectTranscranial light therapyes_ES
dc.subjectLLLTes_ES
dc.subjectSynaptic plasticityes_ES
dc.subjectCognitive functionses_ES
dc.subjectAlzheimer’s disease non-invasive treatmentes_ES
dc.titleThe Transcranial Light Therapy Improves Synaptic Plasticity in the Alzheimer’s Disease Mouse Modeles_ES
dc.typeArtículo de revistaes_ES
uvm.carreraMedicina Veterinariaes_ES
uvm.escuelaEscuela de Ciencias Agrícolas y Veterinariases_ES
uvm.indexWoSes_ES
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