Obesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake

Simple item page
dc.contributor.authorMarcos, José Luis
dc.contributor.authorOlivares-Barraza, Rossy
dc.contributor.authorCeballo, Karina
dc.contributor.authorWastavino, Melisa
dc.contributor.authorOrtiz, Víctor
dc.contributor.authorRiquelme, Julio
dc.contributor.authorMartínez-Pinto, Jonathan
dc.contributor.authorMuñoz, Pablo
dc.contributor.authorCruz, Gonzalo
dc.contributor.authorSotomayor-Zárate, Ramón
dc.date.accessioned2023-09-12T13:26:10Z
dc.date.available2023-09-12T13:26:10Z
dc.date.issued2023-01-11
dc.description.abstractObesity-induced neuroinflammation is a chronic aseptic central nervous system inflammation that presents systemic characteristics associated with increased pro-inflammatory cytokines such as interleukin 1 beta (IL-1β) and interleukin 18 (IL-18) and the presence of microglia and reactive astrogliosis as well as the activation of the NLRP3 inflammasome. The obesity pandemic is associated with lifestyle changes, including an excessive intake of obesogenic foods and decreased physical activity. Brain areas such as the lateral hypothalamus (LH), lateral septum (LS), ventral tegmental area (VTA), and nucleus accumbens (NAcc) have been implicated in the homeostatic and hedonic control of feeding in experimental models of diet-induced obesity. In this context, a chronic lipid intake triggers neuroinflammation in several brain regions such as the hypothalamus, hippocampus, and amygdala. This review aims to present the background defining the significant impact of neuroinflammation and how this, when induced by an obesogenic diet, can affect feeding control, triggering metabolic and neurological alterations.
dc.identifier.issn1422-0067
dc.identifier.other10.3390/ijms24021468
dc.identifier.urihttps://hdl.handle.net/20.500.12536/2049
dc.language.isoen
dc.sourceInternational Journal of Molecular Sciences
dc.subjectDiet
dc.subjectFeeding control
dc.subjectGlia
dc.subjectInflammasome
dc.subjectNeuroinflammation
dc.subjectObesity
dc.titleObesogenic Diet-Induced Neuroinflammation: A Pathological Link between Hedonic and Homeostatic Control of Food Intake
dc.typeArtículo de revista
uvm.escuelaEscuela de Ciencias Agrícolas y Veterinarias
uvm.indexWoS
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Artículo de revista - Obesogenic Diet-Induced Neuroinflammation.pdf
Size:
1.08 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos científicos