Influence of Body Composition on Cardiorespiratory Fitness and Metabolic Markers in Physically Inactive Individuals with Insulin Resistance: An Observational Study

The aim of this study was to determine body composition influence on cardiorespiratory fitness and metabolic markers in physically inactive individuals with insulin resistance (IR). Nineteen overweight and obese (body mass index [BMI] 25.0–29.9 kg·m−2; ≥ 30.0 kg·m−2, respectively) patients diagnosed with IR (5 men and 14 women; age: 32.74 ± 10.07 years; BMI: 32.5 ± 4.60 kg·m−2). The body composition included BMI, fat mass, and fat-free mass. Cardiorespiratory fitness was measured by maximal oxygen uptake (VO2max). Metabolic markers included maximal fat oxidation, fasting glucose, and insulin. IR was determined by homeostatic model assessment (HOMA-IR). The results of the partial correlations (i.e., body mass, age, and sex) reported that fat-free mass, fat mass, and BMI were significantly correlated with VO2max. Additionally, the multiple linear regression model indicated that fat-free mass and BMI explained the variance of VO2max by 89%. However, no substantial correlations were reported between fat mass or fat-free mass with HOMA-IR, fasting glucose, or insulin. This study concluded that a higher percentage of fat-free mass and lower BMI is positively related to better cardiorespiratory fitness despite the IR status of the participants analyzed.
Overweight, Obesity, Body composition, Fitness, Insulin resistance